APLP1 antibody

Catalog No. ABIN7111539

This anti-APLP1 antibody is a Rabbit Polyclonal antibody detecting APLP1 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for APLP1 antibody (ABIN7111539)

Target: APLP1 (Amyloid beta (A4) Precursor-Like Protein 1 (APLP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APLP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-APLP1 Antibody

Purpose: APLP1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: amyloid beta (A4) precursor-like protein 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for APLP1

Target: APLP1 (Amyloid beta (A4) Precursor-Like Protein 1 (APLP1))

Alternative Name: APLP1

Background:

Synonyms: Amyloid beta precursor like protein 1|Amyloid beta (A4) precursor-like protein 1|Amyloid-like protein 1 (APLP, APLP-1)|C30|APLP1

Background: This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

Molecular Weight: 70 kDa

Gene ID: 333

UniProt: P51693

Pathways: cAMP Metabolic Process