Asialoglycoprotein Receptor 1 antibody

Catalog No. ABIN7111748

The Rabbit Polyclonal anti-Asialoglycoprotein Receptor 1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect Asialoglycoprotein Receptor 1 in samples from Human, Mouse and Rat.

Quick Overview for Asialoglycoprotein Receptor 1 antibody (ABIN7111748)

Target: Asialoglycoprotein Receptor 1 (ASGR1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Asialoglycoprotein Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Asialoglycoprotein Receptor 1 Antibody

Purpose: ASGR1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 145-252

Immunogen: asialoglycoprotein receptor 1

Isotype: IgG

Application Details

Application Notes: WB: 1:1000 - 1:4000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Asialoglycoprotein Receptor 1

Target: Asialoglycoprotein Receptor 1 (ASGR1)

Alternative Name: ASGR1

Background:

Synonyms: Asialoglycoprotein receptor 1 (ASGP-R 1, ASGPR 1)|C-type lectin domain family 4 member H1|Hepatic lectin H1 (HL-1)|ASGR1|CLEC4H1

Background: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molecular Weight: 40 kDa

Gene ID: 432

UniProt: P07306

Pathways: Thyroid Hormone Synthesis