ABCC6 antibody

Catalog No. ABIN7111820

The Rabbit Polyclonal anti-ABCC6 antibody has been validated for IHC and ELISA. It is suitable to detect ABCC6 in samples from Human.

Quick Overview for ABCC6 antibody (ABIN7111820)

Target: ABCC6 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-ABCC6 Antibody

Purpose: ABCC6 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1437-1499

Immunogen: ATP-binding cassette, sub-family C (CFTR/MRP), member 6

Isotype: IgG

Application Details

Application Notes: IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ABCC6

Target: ABCC6 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6))

Alternative Name: ABCC6

Background:

Synonyms: ATP-binding cassette sub-family C member 6|Anthracycline resistance-associated protein|Multi-specific organic anion transporter E (MOAT-E)|Multidrug resistance-associated protein 6|ABCC6|ARA|MRP6

Background: The ATP-binding cassette transporter 6 (ABCC6) gene, also named as MRP6, is a cellular transmembrane protein transporter and belongs to ATP-binding cassette (ABC) family. ABCC6 is an ATP-dependent transporter contains two ATP-binding domains. It is mainly found in the liver, the proximal tubules of the kidneys and the intestines. ABCC6 is involved in a pathway of extracellular nucleotide metabolism and the regulation of tissue calcification. Mutations of ABCC6 leads to pseudoxanthoma elasticum (PXE) which is a rare autosomal recessive disorder. Mutations of ABCC6 can also lead generalized arterial calcification of infancy-2 (GACI2).

Molecular Weight: 165 kDa

UniProt: O95255