BBS7 antibody

Catalog No. ABIN7111938

This anti-BBS7 antibody is a Rabbit Polyclonal antibody detecting BBS7 in WB, ELISA, IHC and IP. Suitable for Human and Mouse.

Quick Overview for BBS7 antibody (ABIN7111938)

Target: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-BBS7 Antibody

Purpose: BBS7 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Bardet-Biedl syndrome 7

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000, IP: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for BBS7

Target: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Alternative Name: BBS7

Background:

Synonyms: Bardet-Biedl syndrome 7 protein|BBS2-like protein 1|BBS7|BBS2L1

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Molecular Weight: 80 kDa

Gene ID: 55212

UniProt: Q8IWZ6

Pathways: Hedgehog Signaling