BHLHE22 antibody

Catalog No. ABIN7111942

This Rabbit Polyclonal antibody specifically detects BHLHE22 in WB, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for BHLHE22 antibody (ABIN7111942)

Target: BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BHLHE22 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-BHLHE22 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: basic helix-loop-helix family, member e22

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for BHLHE22

Target: BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))

Alternative Name: BHLHE22

Background: Synonyms:BHLHB5, TNRC20 Background:Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.

Molecular Weight: 37 kDa

Gene ID: 27319

UniProt: Q8NFJ8