BCCIP antibody

Catalog No. ABIN7112053

This Rabbit Polyclonal antibody specifically detects BCCIP in WB, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for BCCIP antibody (ABIN7112053)

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCCIP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-BCCIP Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: BRCA2 and CDKN1A interacting protein

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:100 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3 ,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for BCCIP

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Alternative Name: BCCIP

Background: Synonyms:TOK1 Background:This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 50 kDa

Gene ID: 56647

UniProt: Q9P287