BRD8 antibody (AA 530-920)

Catalog No. ABIN7112079

This anti-BRD8 antibody is a Mouse Monoclonal antibody detecting BRD8 in WB, ELISA, IHC and IF. Suitable for Human.

Quick Overview for BRD8 antibody (AA 530-920) (ABIN7112079)

Target: BRD8 (Bromodomain Containing 8 (BRD8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BRD8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 4B2

Product Details anti-BRD8 Antibody

Binding Specificity: AA 530-920

Purpose: BRD8 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 530-920aa

Immunogen: bromodomain containing 8

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:50-1:500, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for BRD8

Target: BRD8 (Bromodomain Containing 8 (BRD8))

Alternative Name: BRD8

Background:

Synonyms: Bromodomain-containing protein 8|Skeletal muscle abundant protein|Skeletal muscle abundant protein 2|Thyroid hormone receptor coactivating protein of 120 kDa (TrCP120)|p120|BRD8|SMAP|SMAP2

Background: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Molecular Weight: 120 kDa

Gene ID: 10902

UniProt: Q9H0E9