CAMKK2 antibody

Catalog No. ABIN7112196

The Rabbit Polyclonal anti-CAMKK2 antibody (ABIN7112196) specifically detects CAMKK2 in WB, ELISA, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for CAMKK2 antibody (ABIN7112196)

Target: CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMKK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CAMKK2 Antibody

Purpose: CAMKK2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-353

Immunogen: calcium/calmodulin-dependent protein kinase kinase 2, beta

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CAMKK2

Target: CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))

Alternative Name: CAMKK2

Background:

Synonyms: Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2, CaM-kinase kinase 2, CaMKK 2)|Calcium/calmodulin-dependent protein kinase kinase beta (CaM-KK beta, CaM-kinase kinase beta, CaMKK beta)|CAMKK2|CAMKKB|KIAA0787

Background: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase(AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals(By similarity). Seems to be involved in hippocampal activation of CREB1(By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Molecular Weight: 55-60 kDa

Gene ID: 10645

UniProt: Q96RR4

Pathways: AMPK Signaling