Caspase 2 antibody

Catalog No. ABIN7112358

This anti-Caspase 2 antibody is a Mouse Monoclonal antibody detecting Caspase 2 in WB and ELISA. Suitable for Human.

Quick Overview for Caspase 2 antibody (ABIN7112358)

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Caspase 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 2B10

Product Details anti-Caspase 2 Antibody

Purpose: CASP2 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Caspase 2

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000-1:6000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Caspase 2

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Alternative Name: CASP2

Background:

Synonyms: Caspase-2 (CASP-2)|Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD-2)|Protease ICH-1|Caspase-2 subunit p18|Caspase-2 subunit p13|Caspase-2 subunit p12|CASP2|ICH1|NEDD2

Background: CASP2(Caspase-2) is also named as ICH1, NEDD2 and belongs to the peptidase C14A family.It is involved in the activation cascade of caspases responsible for apoptosis execution and might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.It has 2 isoforms produced by alternative splicing and can exists almost as a dimer in solution(PMID:15865942).This antibody can recognize the 32 kDa pro-caspase 2 as well as 18 kDa cleaved-caspase 2.

Molecular Weight: 18, 32, 50 kDa

Gene ID: 835

UniProt: P42575

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway