CBLC antibody

Catalog No. ABIN7112417

The Rabbit Polyclonal anti-CBLC antibody has been validated for WB and ELISA. It is suitable to detect CBLC in samples from Human, Mouse and Rat.

Quick Overview for CBLC antibody (ABIN7112417)

Target: CBLC (Cbl proto-oncogene C (CBLC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBLC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CBLC Antibody

Purpose: CBLC antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Cas-Br-M(murine) ecotropic retroviral transforming sequence c

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CBLC

Target: CBLC (Cbl proto-oncogene C (CBLC))

Alternative Name: CBLC

Background:

Synonyms: E3 ubiquitin-protein ligase CBL-C|RING finger protein 57|RING-type E3 ubiquitin transferase CBL-C|SH3-binding protein CBL-3|SH3-binding protein CBL-C|Signal transduction protein CBL-C|CBLC|CBL3|RNF57

Background: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival.

Molecular Weight: 52 kDa

Gene ID: 23624

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway