CD320 antibody (AA 80-282)

Catalog No. ABIN7112479

This Rabbit Polyclonal antibody specifically detects CD320 in WB, ELISA and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for CD320 antibody (AA 80-282) (ABIN7112479)

Target: CD320 (CD320 Molecule (CD320))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD320 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CD320 Antibody

Binding Specificity: AA 80-282

Purpose: CD320 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 80-282aa

Immunogen: CD320 molecule

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CD320

Target: CD320 (CD320 Molecule (CD320))

Alternative Name: CD320

Background:

Synonyms: CD320 antigen|8D6 antigen|FDC-signaling molecule 8D6 (FDC-SM-8D6)|Transcobalamin receptor (TCblR)|CD320|8D6A

Background: CD320, also known as 8D6, 8D6A or TCblR, is a single-pass type I membrane protein containing 2 LDL-receptor class A domains. Expressed abundantly on follicular dendritic cells (FDCs), CD320 has been shown to enhance proliferation of germinal center (GC) B cells. It is the receptor for cellular uptake of transcobalamin-bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC). CD320 has a calculated molecular mass of 29 kDa. This antibody detects bands at 50-55 kDa and 60-70 kDa, probably caused by extensive complex glycosylation.

Molecular Weight: 50-55 kDa, 60-70 kDa

Gene ID: 51293

UniProt: Q9NPF0