CIDEA antibody

Catalog No. ABIN7112559

This anti-CIDEA antibody is a Rabbit Polyclonal antibody detecting CIDEA in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for CIDEA antibody (ABIN7112559)

Target: CIDEA (Cell Death-Inducing DFFA-Like Effector A (CIDEA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIDEA antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CIDEA Antibody

Purpose: CIDEA antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: cell death-inducing DFFA-like effector a

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CIDEA

Target: CIDEA (Cell Death-Inducing DFFA-Like Effector A (CIDEA))

Alternative Name: CIDEA

Background:

Synonyms: Lipid transferase CIDEA|Cell death activator CIDE-A|Cell death-inducing DFFA-like effector A|CIDEA

Background: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter(By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.

Molecular Weight: 25 kDa

Gene ID: 1149

UniProt: O60543