CHMP6 antibody

Catalog No. ABIN7112649

This anti-CHMP6 antibody is a Rabbit Polyclonal antibody detecting CHMP6 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for CHMP6 antibody (ABIN7112649)

Target: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CHMP6 Antibody

Purpose: CHMP6 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: chromatin modifying protein 6

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CHMP6

Target: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Alternative Name: CHMP6

Background:

Synonyms: Charged multivesicular body protein 6|Chromatin-modifying protein 6|Vacuolar protein sorting-associated protein 20 (Vps20, hVps20)|CHMP6|VPS20

Background: Probable core component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

Molecular Weight: 28-30 kDa

Gene ID: 79643

UniProt: Q96FZ7