CXCR4 antibody (AA 200-352)

Catalog No. ABIN7112680

This Mouse Monoclonal antibody specifically detects CXCR4 in WB, ELISA and FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for CXCR4 antibody (AA 200-352) (ABIN7112680)

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CXCR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 9H1

Product Details anti-CXCR4 Antibody

Binding Specificity: AA 200-352

Purpose: CXCR4 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 200-352aa

Immunogen: chemokine(C-X-C motif) receptor 4

Isotype: IgG2a

Application Details

Application Notes: WB: 1:500-1:5000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CXCR4

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Alternative Name: CXCR4

Background:

Synonyms: C-X-C chemokine receptor type 4 (CXC-R4, CXCR-4)|FB22|Fusin|HM89|LCR1|Leukocyte-derived seven transmembrane domain receptor (LESTR)|Lipopolysaccharide-associated protein 3 (LAP-3, LPS-associated protein 3)|NPYRL|Stromal cell-derived factor 1 receptor (SDF-1 receptor)|CXCR4

Background: The chemokine receptor CXCR4, a 7-transmembrane protein on cell surface, acts with the CD4 protein to support HIV entry into cells. CXCR4 is highly expressed in brain and heart, white blood cells, vascular endothelial cells, and umbilical cord endothelial cells. Several CXCR4 isoforms have been identified with molecular weights of 47, 50, 62 and 98 kDa. The 62-64 kDa CXCR4 is predominantly ubiquitinated and is preferentially associated with CD4. This antibody recognizes the 62kd CXCR4.

Molecular Weight: 60-70 kDa

Gene ID: 7852

UniProt: P61073

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events