CX3CL1 antibody (AA 90-245)

Catalog No. ABIN7112685

This anti-CX3CL1 antibody is a Mouse Monoclonal antibody detecting CX3CL1 in WB, IHC and ELISA. Suitable for Human.

Quick Overview for CX3CL1 antibody (AA 90-245) (ABIN7112685)

Target: CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CX3CL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 5D1

Product Details anti-CX3CL1 Antibody

Binding Specificity: AA 90-245

Purpose: CX3CL1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 90-245aa

Immunogen: chemokine(C-X3-C motif) ligand 1

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CX3CL1

Target: CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

Alternative Name: CX3CL1

Background:

Synonyms: Fractalkine|C-X3-C motif chemokine 1|CX3C membrane-anchored chemokine|Neurotactin|Small-inducible cytokine D1|Processed fractalkine|CX3CL1|FKN|NTT|SCYD1

Background: Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1(PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site(site 1) in integrins. In the absence of CX3CR1, binds to a second site(site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1(PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium(PubMed:9024663, PubMed:9177350).

Molecular Weight: 90 kDa

Gene ID: 6376

UniProt: P78423

Pathways: Synaptic Membrane