Clusterin antibody (AA 100-449)

Catalog No. ABIN7112893

This Mouse Monoclonal antibody specifically detects Clusterin in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Clusterin antibody (AA 100-449) (ABIN7112893)

Target: Clusterin (CLU)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 5A5

Product Details anti-Clusterin Antibody

Binding Specificity: AA 100-449

Purpose: CLU antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 100-449aa

Immunogen: clusterin

Isotype: IgG2a

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: CLU

Background:

Synonyms: Clusterin|Aging-associated gene 4 protein|Apolipoprotein J (Apo-J)|Complement cytolysis inhibitor (CLI)|Complement-associated protein SP-40,40|Ku70-binding protein 1|NA1/NA2|Sulfated glycoprotein 2 (SGP-2)|Testosterone-repressed prostate message 2 (TRPM-2)|Clusterin beta chain Alternative names: ApoJalpha|Complement cytolysis inhibitor a chain|SP-40,40 beta-chain|Clusterin alpha chain Alternative names: ApoJbeta|Complement cytolysis inhibitor b chain|SP-40,40 alpha-chain|CLU|APOJ|CLI|KUB1

Background: Clusterin (Apolipoprotein J) is a 75-80 kDa heterodimeric glycoprotein produced by a wide array of tissues and found in most biologic fluids (PMID: 7648419, 11906815). It is encoded by one single gene and cleaved posttranslationally into α (34-36 kDa) and β (36-39 kDa) subunits prior to secretion from the cell. Many functions have been described for clusterin, including regulating apoptosis, transporting lipids, controlling cell interactions, regulating complement (PMID: 10694874).

Molecular Weight: 36 kDa

Gene ID: 1191

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling