CNDP2 antibody

Catalog No. ABIN7112896

This Rabbit Polyclonal antibody specifically detects CNDP2 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CNDP2 antibody (ABIN7112896)

Target: CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNDP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-CNDP2 Antibody

Purpose: CNDP2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: CNDP dipeptidase 2(metallopeptidase M20 family)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CNDP2

Target: CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2))

Alternative Name: CNDP2

Background:

Synonyms: Cytosolic non-specific dipeptidase|CNDP dipeptidase 2|Glutamate carboxypeptidase-like protein 1|Peptidase A|Threonyl dipeptidase|CNDP2|CN2|CPGL|HEL-S-13|PEPA

Background: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly(PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase(MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation(PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma(HCC) cells(PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis(PubMed:25964343).

Molecular Weight: 54 kDa

Gene ID: 55748

UniProt: Q96KP4