COBRA1 antibody

Catalog No. ABIN7112923

This Rabbit Polyclonal antibody specifically detects COBRA1 in WB, ELISA, IF and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for COBRA1 antibody (ABIN7112923)

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COBRA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-COBRA1 Antibody

Purpose: NELFB antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: cofactor of BRCA1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:500-1:1000, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for COBRA1

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Alternative Name: NELFB

Background:

Synonyms: Negative elongation factor B (NELF-B)|Cofactor of BRCA1|NELFB|COBRA1|KIAA1182

Background: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding.

Molecular Weight: 66 kDa

Gene ID: 25920

UniProt: Q8WX92