CC2D1A antibody

Catalog No. ABIN7112928

This anti-CC2D1A antibody is a Rabbit Polyclonal antibody detecting CC2D1A in WB, IHC, ELISA and IF. Suitable for Human, Mouse and Rat.

Quick Overview for CC2D1A antibody (ABIN7112928)

Target: CC2D1A (Coiled-Coil and C2 Domain Containing 1A (CC2D1A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CC2D1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-CC2D1A Antibody

Purpose: CC2D1A antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: coiled-coil and C2 domain containing 1A

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CC2D1A

Target: CC2D1A (Coiled-Coil and C2 Domain Containing 1A (CC2D1A))

Alternative Name: CC2D1A

Background:

Synonyms: Coiled-coil and C2 domain-containing protein 1A|Akt kinase-interacting protein 1|Five prime repressor element under dual repression-binding protein 1 (FRE under dual repression-binding protein 1, Freud-1)|Putative NF-kappa-B-activating protein 023N|CC2D1A|AKI1

Background: Transcription factor that binds specifically to the DRE(dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses(By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.

Molecular Weight: 130 kDa, 104 kDa

Gene ID: 54862

UniProt: Q6P1N0