Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CYLD antibody

This anti-CYLD antibody is a Rabbit Polyclonal antibody detecting CYLD in WB, ELISA, IHC and IP. Suitable for Human, Mouse and Rat.
Catalog No. ABIN7113186

Quick Overview for CYLD antibody (ABIN7113186)

Target

See all CYLD Antibodies
CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivity

  • 44
  • 21
  • 16
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Mouse, Rat

Host

  • 37
  • 7
  • 1
Rabbit

Clonality

  • 38
  • 7
Polyclonal

Conjugate

  • 21
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CYLD antibody is un-conjugated

Application

  • 30
  • 13
  • 8
  • 5
  • 5
  • 4
  • 4
  • 4
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • Purification

    Immunogen affinity purified

    Purity

    ≥95 % as determined by SDS-PAGE

    Immunogen

    cylindromatosis(turban tumor syndrome)

    Isotype

    IgG
  • Application Notes

    WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:50-1:500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Expiry Date

    12 months
  • Target

    CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

    Alternative Name

    CYLD

    Background

    Synonyms:CYLD1, KIAA0849 Background:Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation(PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation(PubMed:12917690). Negative regulator of Wnt signaling(PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules(PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis(PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis(PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation(PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis(By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation(By similarity).

    Molecular Weight

    110 kDa

    UniProt

    Q9NQC7

    Pathways

    Apoptosis, Activation of Innate immune Response
You are here:
Chat with us!