DACH2 antibody

Catalog No. ABIN7113311

The Rabbit Polyclonal anti-DACH2 antibody has been validated for WB and ELISA. It is suitable to detect DACH2 in samples from Human and Mouse.

Quick Overview for DACH2 antibody (ABIN7113311)

Target: DACH2 (Dachshund 2 (DACH2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DACH2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DACH2 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: dachshund homolog 2(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for DACH2

Target: DACH2 (Dachshund 2 (DACH2))

Alternative Name: DACH2

Background: Synonyms: Background:Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression(By similarity). Probably binds to DNA via its DACHbox-N domain.

Molecular Weight: 65 kDa

Gene ID: 117154

UniProt: Q96NX9