DDX58 antibody

Catalog No. ABIN7113355

This Rabbit Polyclonal antibody specifically detects DDX58 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human and Rat.

Quick Overview for DDX58 antibody (ABIN7113355)

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDX58 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-DDX58 Antibody

Purpose: RIGI antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: DEAD(Asp-Glu-Ala-Asp) box polypeptide 58

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DDX58

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Alternative Name: RIGI

Background:

Synonyms: Antiviral innate immune response receptor RIG-I|ATP-dependent RNA helicase DDX58|DEAD box protein 58|RIG-I-like receptor 1 (RLR-1)|RNA sensor RIG-I|Retinoic acid-inducible gene 1 protein (RIG-1)|Retinoic acid-inducible gene I protein (RIG-I)|RIGI|DDX58

Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp(DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain(CARD). It is involved in viral double-stranded(ds) RNA recognition and the regulation of immune response.

Molecular Weight: 110 kDa

Gene ID: 23586

UniProt: O95786

Pathways: Activation of Innate immune Response, Hepatitis C