DOCK7 antibody

Catalog No. ABIN7113381

The Rabbit Polyclonal anti-DOCK7 antibody (ABIN7113381) specifically detects DOCK7 in WB, ELISA and IP. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for DOCK7 antibody (ABIN7113381)

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-DOCK7 Antibody

Purpose: DOCK7 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: dedicator of cytokinesis 7

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IP: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DOCK7

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Alternative Name: DOCK7

Background:

Synonyms: Dedicator of cytokinesis protein 7|DOCK7|KIAA1771

Background: Functions as a guanine nucleotide exchange factor(GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization(PubMed:16982419). Has a role in pigmentation(By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells(RGCs) proliferation versus differentiation, negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3(By similarity).Multiple isoforms of DOCK 7 exist due to alternative splicing events. This DOCK 7 antibody can recognize all the isoforms.

Molecular Weight: 240 kDa

Gene ID: 85440

UniProt: Q96N67