DNAJC10 antibody

Catalog No. ABIN7113582

This anti-DNAJC10 antibody is a Rabbit Polyclonal antibody detecting DNAJC10 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for DNAJC10 antibody (ABIN7113582)

Target: DNAJC10 (DnaJ (Hsp40) Homolog, Subfamily C, Member 10 (DNAJC10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJC10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-DNAJC10 Antibody

Purpose: DNAJC10 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: DnaJ(Hsp40) homolog, subfamily C, member 10

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DNAJC10

Target: DNAJC10 (DnaJ (Hsp40) Homolog, Subfamily C, Member 10 (DNAJC10))

Alternative Name: DNAJC10

Background:

Synonyms: DnaJ homolog subfamily C member 10|Endoplasmic reticulum DNA J domain-containing protein 5 (ER-resident protein ERdj5, ERdj5)|Macrothioredoxin (MTHr)|DNAJC10|ERDJ5

Background: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation(ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.

Molecular Weight: 75-80 kDa

Gene ID: 54431

UniProt: Q8IXB1

Pathways: Cell RedoxHomeostasis