DOC2B antibody

Catalog No. ABIN7113615

This anti-DOC2B antibody is a Rabbit Polyclonal antibody detecting DOC2B in ELISA, WB and IF. Suitable for Human, Rat and Mouse.

Quick Overview for DOC2B antibody (ABIN7113615)

Target: DOC2B (Double C2-Like Domains, beta (DOC2B))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOC2B antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-DOC2B Antibody

Purpose: DOC2B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: double C2-like domains, beta

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DOC2B

Target: DOC2B (Double C2-Like Domains, beta (DOC2B))

Alternative Name: DOC2B

Background:

Synonyms: Double C2-like domain-containing protein beta (Doc2-beta)|DOC2B|DOC2BL

Background: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes(By similarity).

Molecular Weight: 46 kDa

Gene ID: 8447

UniProt: Q14184

Pathways: Positive Regulation of Peptide Hormone Secretion