EPH Receptor A8 antibody

Catalog No. ABIN7113851

The Rabbit Polyclonal anti-EPH Receptor A8 antibody has been validated for ELISA and WB. It is suitable to detect EPH Receptor A8 in samples from Human, Mouse and Rat.

Quick Overview for EPH Receptor A8 antibody (ABIN7113851)

Target: EPH Receptor A8 (EPHA8)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A8 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-EPH Receptor A8 Antibody

Purpose: EPHA8 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: EPH receptor A8

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for EPH Receptor A8

Target: EPH Receptor A8 (EPHA8)

Alternative Name: EPHA8

Background:

Synonyms: Ephrin type-A receptor 8|EPH- and ELK-related kinase|EPH-like kinase 3 (EK3, hEK3)|Tyrosine-protein kinase receptor EEK|EPHA8|EEK|HEK3|KIAA1459

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth(By similarity).

Molecular Weight: 120 kDa

Gene ID: 2046

UniProt: P29322

Pathways: RTK Signaling