EDEM2 antibody

Catalog No. ABIN7113869

The Rabbit Polyclonal anti-EDEM2 antibody has been validated for ELISA and WB. It is suitable to detect EDEM2 in samples from Human, Mouse and Rat.

Quick Overview for EDEM2 antibody (ABIN7113869)

Target: EDEM2 (ER Degradation Enhancer, Mannosidase alpha-Like 2 (EDEM2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EDEM2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-EDEM2 Antibody

Purpose: EDEM2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ER degradation enhancer, mannosidase alpha-like 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for EDEM2

Target: EDEM2 (ER Degradation Enhancer, Mannosidase alpha-Like 2 (EDEM2))

Alternative Name: EDEM2

Background:

Synonyms: ER degradation-enhancing alpha-mannosidase-like protein 2|EDEM2|C20orf31|C20orf49

Background: Initiates the endoplasmic reticulum-associated degradation(ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2(PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.

Molecular Weight: 60-65 kDa

Gene ID: 55741

UniProt: Q9BV94