EXD1 antibody

Catalog No. ABIN7114002

This anti-EXD1 antibody is a Rabbit Polyclonal antibody detecting EXD1 in WB, IF, ELISA and IHC. Suitable for Human, Rat and Mouse.

Quick Overview for EXD1 antibody (ABIN7114002)

Target: EXD1 (Exonuclease 3'-5' Domain Containing 1 (EXD1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (IHC)

Product Details anti-EXD1 Antibody

Purpose: EXD1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: exonuclease 3'-5' domain containing 1

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IHC: 1:50-1:500, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for EXD1

Target: EXD1 (Exonuclease 3'-5' Domain Containing 1 (EXD1))

Alternative Name: EXD1

Background:

Synonyms: piRNA biogenesis protein EXD1|Exonuclease 3'-5' domain-containing protein 1|Exonuclease 3'-5' domain-like-containing protein 1|Inactive exonuclease EXD1|EXD1|EXDL1

Background: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity(By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease(By similarity).

Molecular Weight: 36 kDa

Gene ID: 161829

UniProt: Q8NHP7