EYA2 antibody

Catalog No. ABIN7114029

This anti-EYA2 antibody is a Rabbit Polyclonal antibody detecting EYA2 in WB, ELISA and IHC. Suitable for Human, Rat and Mouse.

Quick Overview for EYA2 antibody (ABIN7114029)

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-EYA2 Antibody

Purpose: EYA2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: eyes absent homolog 2(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for EYA2

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Alternative Name: EYA2

Background:

Synonyms: Eyes absent homolog 2|EYA2|EAB1

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5(PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX(H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress(PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1(PubMed:12500905).

Molecular Weight: 57 kDa

Gene ID: 2139

UniProt: O00167