F-Box Protein 3 antibody

Catalog No. ABIN7114048

This Rabbit Polyclonal antibody specifically detects F-Box Protein 3 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for F-Box Protein 3 antibody (ABIN7114048)

Target: F-Box Protein 3 (FBXO3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This F-Box Protein 3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-F-Box Protein 3 Antibody

Purpose: FBXO3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: F-box protein 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for F-Box Protein 3

Target: F-Box Protein 3 (FBXO3)

Alternative Name: FBXO3

Background:

Synonyms: F-box only protein 3|FBXO3|FBX3

Background: Substrate recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

Molecular Weight: 48-50 kDa

Gene ID: 26273

UniProt: Q9UK99