BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) antibody

Catalog No. ABIN7114081

This Rabbit Polyclonal antibody specifically detects in WB, IHC, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) antibody (ABIN7114081)

Target: BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details

Purpose: ABRAXAS1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: family with sequence similarity 175, member A

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2400, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details

Target: BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)

Alternative Name: ABRAXAS1

Background:

Synonyms: BRCA1-A complex subunit Abraxas 1|Coiled-coil domain-containing protein 98|Protein FAM175A|ABRAXAS1|ABRA1|CCDC98|FAM175A

Background: Involved in DNA damage response and double-strand break(DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

Molecular Weight: 46 kDa

Gene ID: 84142

UniProt: Q6UWZ7