FAM20C antibody (AA 102-330)

Catalog No. ABIN7114089

This anti-FAM20C antibody is a Rabbit Polyclonal antibody detecting FAM20C in WB, ELISA and IHC. Suitable for Human, Rat and Mouse.

Quick Overview for FAM20C antibody (AA 102-330) (ABIN7114089)

Target: FAM20C (Family with Sequence Similarity 20, Member C (FAM20C))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM20C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-FAM20C Antibody

Binding Specificity: AA 102-330

Purpose: FAM20C antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 102-330 aa

Immunogen: family with sequence similarity 20, member C

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for FAM20C

Target: FAM20C (Family with Sequence Similarity 20, Member C (FAM20C))

Alternative Name: FAM20C

Background:

Synonyms: Extracellular serine/threonine protein kinase FAM20C|Dentin matrix protein 4 (DMP-4)|Golgi casein kinase|Golgi-enriched fraction casein kinase (GEF-CK)|FAM20C|DMP4

Background: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth(PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome(PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity(PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1(PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion(PubMed:26091039).

Molecular Weight: 50 kDa

Gene ID: 56975

UniProt: Q8IXL6