GPSM1 antibody

Catalog No. ABIN7114427

The Rabbit Polyclonal anti-GPSM1 antibody has been validated for ELISA, WB, IHC and IF. It is suitable to detect GPSM1 in samples from Human, Mouse and Rat.

Quick Overview for GPSM1 antibody (ABIN7114427)

Target: GPSM1 (G-Protein Signaling Modulator 1 (GPSM1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPSM1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GPSM1 Antibody

Purpose: GPSM1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: G-protein signaling modulator 1(AGS3-like, C. elegans)

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IF: 1:10-1:100, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GPSM1

Target: GPSM1 (G-Protein Signaling Modulator 1 (GPSM1))

Alternative Name: GPSM1

Background:

Synonyms: G-protein-signaling modulator 1|Activator of G-protein signaling 3|GPSM1|AGS3

Background: GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory(GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate(GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein(p-CREB).

Molecular Weight: 72 kDa

Gene ID: 26086

UniProt: Q86YR5

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling