GNB5 antibody

Catalog No. ABIN7114820

The Rabbit Polyclonal anti-GNB5 antibody has been validated for WB, ELISA, IHC and IP. It is suitable to detect GNB5 in samples from Human, Mouse and Rat.

Quick Overview for GNB5 antibody (ABIN7114820)

Target: GNB5 (Guanine Nucleotide Binding Protein (G Protein), beta 5 (GNB5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNB5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-GNB5 Antibody

Purpose: GNB5 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: guanine nucleotide binding protein(G protein), beta 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GNB5

Target: GNB5 (Guanine Nucleotide Binding Protein (G Protein), beta 5 (GNB5))

Alternative Name: GNB5

Background:

Synonyms: Guanine nucleotide-binding protein subunit beta-5|Gbeta5|Transducin beta chain 5|GNB5

Background: Heterotrimeric guanine nucleotide-binding proteins(G proteins) function as transducers downstream of G protein-coupled receptors(GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Molecular Weight: 39-42 kDa

Gene ID: 10681

UniProt: O14775

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling