Macro H2A.2 antibody

Catalog No. ABIN7114849

This Rabbit Polyclonal antibody specifically detects Macro H2A.2 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Macro H2A.2 antibody (ABIN7114849)

Target: Macro H2A.2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details

Purpose: MACROH2A2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: H2A histone family, member Y2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details

Target: Macro H2A.2

Alternative Name: MACROH2A2

Background:

Synonyms: Core histone macro-H2A.2 (Histone macroH2A2, mH2A2)|MACROH2A2|H2AFY2

Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Molecular Weight: 40 kDa

Gene ID: 55506

UniProt: Q9P0M6