HARS2 antibody

Catalog No. ABIN7115030

The Rabbit Polyclonal anti-HARS2 antibody has been validated for WB, ELISA and IHC. It is suitable to detect HARS2 in samples from Human, Mouse and Rat.

Quick Overview for HARS2 antibody (ABIN7115030)

Target: HARS2 (Histidyl-tRNA Synthetase 2, Mitochondrial (Putative) (HARS2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HARS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-HARS2 Antibody

Purpose: HARS2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: histidyl-tRNA synthetase 2, mitochondrial (putative)

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for HARS2

Target: HARS2 (Histidyl-tRNA Synthetase 2, Mitochondrial (Putative) (HARS2))

Alternative Name: HARS2

Background:

Synonyms: Histidine--tRNA ligase, mitochondrial|Histidine--tRNA ligase-like|Histidyl-tRNA synthetase (HisRS)|HARS2|HARSL|HARSR|HO3

Background: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene.

Molecular Weight: 50 kDa

Gene ID: 23438

UniProt: P49590