Histone Cluster 3, H3 (HIST3H3) antibody

Catalog No. ABIN7115040

The Rabbit Polyclonal anti-Histone Cluster 3, H3 antibody (ABIN7115040) specifically detects Histone Cluster 3, H3 in ELISA, WB, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Histone Cluster 3, H3 (HIST3H3) antibody (ABIN7115040)

Target: Histone Cluster 3, H3 (HIST3H3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details

Purpose: Histone-H3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: histone cluster 2, H3a

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:50-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details

Target: Histone Cluster 3, H3 (HIST3H3)

Alternative Name: Histone-H3

Background:

Synonyms: Histone H3.2|H3-clustered histone 13|H3-clustered histone 14|H3-clustered histone 15|Histone H3/m|Histone H3/o|H3C15|HIST2H3A

Background: HIST2H3A,histone cluster 2, H3a.It is the core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. HIST2H3A is Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.

Molecular Weight: 15-17 kDa

Gene ID: 333932

UniProt: Q71DI3