Histone Cluster 3, H3 (HIST3H3) antibody

Catalog No. ABIN7115040

This anti- antibody is a Rabbit Polyclonal antibody detecting in ELISA, WB, IHC and IF. Suitable for Human, Mouse and Rat.

Quick Overview for Histone Cluster 3, H3 (HIST3H3) antibody (ABIN7115040)

Target: Histone Cluster 3, H3 (HIST3H3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details

Purpose: Histone-H3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: histone cluster 2, H3a

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:50-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details

Target: Histone Cluster 3, H3 (HIST3H3)

Alternative Name: Histone-H3

Background:

Synonyms: Histone H3.2|H3-clustered histone 13|H3-clustered histone 14|H3-clustered histone 15|Histone H3/m|Histone H3/o|H3C15|HIST2H3A

Background: HIST2H3A,histone cluster 2, H3a.It is the core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. HIST2H3A is Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.

Molecular Weight: 15-17 kDa

Gene ID: 333932

UniProt: Q71DI3