HSD17B11 antibody (AA 28-300)

Catalog No. ABIN7115150

The Rabbit Polyclonal anti-HSD17B11 antibody has been validated for ELISA, WB and IHC. It is suitable to detect HSD17B11 in samples from Human, Rat and Mouse.

Quick Overview for HSD17B11 antibody (AA 28-300) (ABIN7115150)

Target: HSD17B11 (Hydroxysteroid (17-Beta) Dehydrogenase 11 (HSD17B11))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B11 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HSD17B11 Antibody

Binding Specificity: AA 28-300

Purpose: HSD17B11 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 28-300aa

Immunogen: hydroxysteroid(17-beta) dehydrogenase 11

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for HSD17B11

Target: HSD17B11 (Hydroxysteroid (17-Beta) Dehydrogenase 11 (HSD17B11))

Alternative Name: HSD17B11

Background:

Synonyms: Estradiol 17-beta-dehydrogenase 11|17-beta-hydroxysteroid dehydrogenase 11 (17-beta-HSD 11, 17bHSD11, 17betaHSD11)|17-beta-hydroxysteroid dehydrogenase XI (17-beta-HSD XI, 17betaHSDXI)|Cutaneous T-cell lymphoma-associated antigen HD-CL-03 (CTCL-associated antigen HD-CL-03)|Dehydrogenase/reductase SDR family member 8|Retinal short-chain dehydrogenase/reductase 2 (retSDR2)|Short chain dehydrogenase/reductase family 16C member 2|HSD17B11|DHRS8|PAN1B|SDR16C2

Background: Can convert androstan-3-alpha,17-beta-diol(3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA(dehydroepiandrosterone), or A-dione(4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

Molecular Weight: 33 kDa

Gene ID: 51170

UniProt: Q8NBQ5