IDS antibody (AA 1-300)

Catalog No. ABIN7115175

This anti-IDS antibody is a Mouse Monoclonal antibody detecting IDS in WB, IHC, ELISA and IF. Suitable for Human.

Quick Overview for IDS antibody (AA 1-300) (ABIN7115175)

Target: IDS (Iduronate 2-Sulfatase (IDS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IDS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 2D2

Product Details anti-IDS Antibody

Binding Specificity: AA 1-300

Purpose: IDS antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-300aa

Immunogen: iduronate 2-sulfatase

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IDS

Target: IDS (Iduronate 2-Sulfatase (IDS))

Alternative Name: IDS

Background:

Synonyms: Iduronate 2-sulfatase|Alpha-L-iduronate sulfate sulfatase (Idursulfase)|Iduronate 2-sulfatase 42 kDa chain|Iduronate 2-sulfatase 14 kDa chain|IDS|SIDS

Background: Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).

Molecular Weight: 76 kDa, 55 kDa

Gene ID: 3423

UniProt: P22304

Pathways: Glycosaminoglycan Metabolic Process