ITGA5 antibody

Catalog No. ABIN7115337

This anti-ITGA5 antibody is a Rabbit Polyclonal antibody detecting ITGA5 in WB and ELISA. Suitable for Human, Mouse, Rat and Monkey.

Quick Overview for ITGA5 antibody (ABIN7115337)

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ITGA5 Antibody

Purpose: ITGA5 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: integrin, alpha 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ITGA5

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Alternative Name: ITGA5

Background:

Synonyms: Integrin alpha-5|CD49 antigen-like family member E|Fibronectin receptor subunit alpha|Integrin alpha-F|VLA-5|Integrin alpha-5 heavy chain|Integrin alpha-5 light chain|ITGA5|FNRA

Background: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site(site 2) which is distinct from the classical ligand-binding site(site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1(PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1(FBN1) and mediates R-G-D-dependent cell adhesion to FBN1(PubMed:12807887, PubMed:17158881).

Molecular Weight: 120 kDa

UniProt: P08648

Pathways: Integrin Complex