IL23A antibody (AA 20-189)

Catalog No. ABIN7115450

The Mouse Monoclonal anti-IL23A antibody has been validated for WB, ELISA and IHC. It is suitable to detect IL23A in samples from Human.

Quick Overview for IL23A antibody (AA 20-189) (ABIN7115450)

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL23A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 2G1

Product Details anti-IL23A Antibody

Binding Specificity: AA 20-189

Purpose: IL23A antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 20-189aa

Immunogen: interleukin 23, alpha subunit p19

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IL23A

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Alternative Name: IL23A

Background:

Synonyms: Interleukin-23 subunit alpha (IL-23 subunit alpha, IL-23-A)|Interleukin-23 subunit p19 (IL-23p19)|IL23A|SGRF

Background: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Molecular Weight: 21 kDa

Gene ID: 51561

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation