KISS1 antibody (AA 124-138)

Catalog No. ABIN7115721

This anti-KISS1 antibody is a Rabbit Polyclonal antibody detecting KISS1 in WB, IHC, ELISA and IF. Suitable for Human and Mouse.

Quick Overview for KISS1 antibody (AA 124-138) (ABIN7115721)

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KISS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-KISS1 Antibody

Binding Specificity: AA 124-138

Purpose: KISS1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: A synthetic peptide,124-138aa

Immunogen: KiSS-1 metastasis-suppressor

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for KISS1

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Alternative Name: KISS1

Background:

Synonyms: Metastasis-suppressor KiSS-1|Kisspeptin-1|Metastin Alternative names: Kisspeptin-54|Kisspeptin-14|Kisspeptin-13|Kisspeptin-10|KISS1

Background: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

Molecular Weight: 16-20 kDa

Gene ID: 3814

UniProt: Q15726

Pathways: Positive Regulation of Peptide Hormone Secretion