LRRC8D antibody

Catalog No. ABIN7115814

This anti-LRRC8D antibody is a Rabbit Polyclonal antibody detecting LRRC8D in ELISA and WB. Suitable for Human, Mouse and Rat.

Quick Overview for LRRC8D antibody (ABIN7115814)

Target: LRRC8D (Leucine Rich Repeat Containing 8 Family, Member D (LRRC8D))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC8D antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-LRRC8D Antibody

Purpose: LRRC8D antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: leucine rich repeat containing 8 family, member D

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for LRRC8D

Target: LRRC8D (Leucine Rich Repeat Containing 8 Family, Member D (LRRC8D))

Alternative Name: LRRC8D

Background:

Synonyms: Volume-regulated anion channel subunit LRRC8D|Leucine-rich repeat-containing protein 5|Leucine-rich repeat-containing protein 8D (HsLRRC8D)|LRRC8D|LRRC5

Background: Non-essential component of the volume-regulated anion channel(VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member(LRRC8B, LRRC8C, LRRC8D or LRRC8E), channel characteristics depend on the precise subunit composition(PubMed:24790029, PubMed:26824658). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin(PubMed:26530471). Mediates the import of the antibiotic blasticidin-S into the cell(PubMed:24782309).

Molecular Weight: 98-120 kDa

Gene ID: 55144

UniProt: Q7L1W4