LRWD1 antibody

Catalog No. ABIN7115828

The Rabbit Polyclonal anti-LRWD1 antibody has been validated for WB and ELISA. It is suitable to detect LRWD1 in samples from Human.

Quick Overview for LRWD1 antibody (ABIN7115828)

Target: LRWD1 (Leucine-Rich Repeat and WD Repeat-Containing Protein 1 (LRWD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRWD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LRWD1 Antibody

Purpose: LRWD1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: leucine-rich repeats and WD repeat domain containing 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for LRWD1

Target: LRWD1 (Leucine-Rich Repeat and WD Repeat-Containing Protein 1 (LRWD1))

Alternative Name: LRWD1

Background:

Synonyms: Leucine-rich repeat and WD repeat-containing protein 1|Centromere protein 33 (CENP-33)|Origin recognition complex-associated protein (ORC-associated protein, ORCA)|LRWD1|CENP-33|ORCA

Background: Required for G1/S transition. Recruits and stabilizes the origin recognition complex(ORC) onto chromatin during G1 to establish pre-replication complex(preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

Molecular Weight: 85 kDa

Gene ID: 222229

UniProt: Q9UFC0

Pathways: Chromatin Binding