MSL1 antibody (AA 473-614)

Catalog No. ABIN7116032

The Rabbit Polyclonal anti-MSL1 antibody has been validated for WB and ELISA. It is suitable to detect MSL1 in samples from Human.

Quick Overview for MSL1 antibody (AA 473-614) (ABIN7116032)

Target: MSL1 (Male-Specific Lethal 1 Homolog (MSL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MSL1 Antibody

Binding Specificity: AA 473-614

Purpose: MSL1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 473-614aa

Immunogen: male-specific lethal 1 homolog(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MSL1

Target: MSL1 (Male-Specific Lethal 1 Homolog (MSL1))

Alternative Name: MSL1

Background:

Synonyms: Male-specific lethal 1 homolog (MSL-1)|Male-specific lethal 1-like 1 (MSL1-like 1)|Male-specific lethal-1 homolog 1|MSL1|MSL1L1

Background: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16'(H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34'(H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4'(H3K4me) and 'Lys-79'(H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.

Molecular Weight: 67 kDa

Gene ID: 339287

UniProt: Q68DK7