MME antibody

Catalog No. ABIN7116192

The Mouse Monoclonal anti-MME antibody (Clone 1H6) (ABIN7116192) specifically detects MME in WB, IHC and ELISA. The antibody is reactive with Human and Pig samples.

Quick Overview for MME antibody (ABIN7116192)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reactivity: Human, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This MME antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 1H6

Product Details anti-MME Antibody

Purpose: MME antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: membrane metallo-endopeptidase

Isotype: IgG2a

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: MME

Background:

Synonyms: Neprilysin|Atriopeptidase|Common acute lymphocytic leukemia antigen (CALLA)|Enkephalinase|Neutral endopeptidase 24.11 (NEP, Neutral endopeptidase)|Skin fibroblast elastase (SFE)|MME|EPN

Background: MME is also names as neprilysin,CALLA,NEP,SFE,CD10 and belongs to the peptidase M13 family.It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium.CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas(PMID:15286660).This antibody is specific to MME.

Molecular Weight: 90-110 kDa

Gene ID: 4311

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration