MARCHF8 antibody

Catalog No. ABIN7116199

This Rabbit Polyclonal antibody specifically detects in ELISA, WB and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MARCHF8 antibody (ABIN7116199)

Target: MARCHF8

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Product Details

Purpose: MARCHF8 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: membrane-associated ring finger(C3HC4) 8

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IP: 1:200-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details

Target: MARCHF8

Background:

Synonyms: E3 ubiquitin-protein ligase MARCHF8|Cellular modulator of immune recognition (c-MIR)|Membrane-associated RING finger protein 8|Membrane-associated RING-CH protein VIII (MARCH-VIII)|RING finger protein 178|RING-type E3 ubiquitin transferase MARCHF8|MARCHF8|MARCH8|MIR|RNF178

Background: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Molecular Weight: 33 kDa

Gene ID: 220972

UniProt: Q5T0T0