MICAL1 antibody

Catalog No. ABIN7116285

This anti-MICAL1 antibody is a Rabbit Polyclonal antibody detecting MICAL1 in WB, FACS, IHC, ELISA and IP. Suitable for Human and Mouse.

Quick Overview for MICAL1 antibody (ABIN7116285)

Target: MICAL1 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 1 (MICAL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MICAL1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Product Details anti-MICAL1 Antibody

Purpose: MICAL1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: microtubule associated monoxygenase, calponin and LIM domain containing 1

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:4000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MICAL1

Target: MICAL1 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 1 (MICAL1))

Alternative Name: MICAL1

Background:

Synonyms: [F-actin]-monooxygenase MICAL1|Molecule interacting with CasL protein 1 (MICAL-1)|NEDD9-interacting protein with calponin homology and LIM domains|MICAL1|MICAL|NICAL

Background: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization(Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L, acts by antagonizing STK38 and STK38L activation by MST1/STK4.

Molecular Weight: 120 kDa

Gene ID: 64780

UniProt: Q8TDZ2