MUL1 antibody

Catalog No. ABIN7116330

This anti-MUL1 antibody is a Rabbit Polyclonal antibody detecting MUL1 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for MUL1 antibody (ABIN7116330)

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MUL1 Antibody

Purpose: MUL1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: mitochondrial E3 ubiquitin ligase 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MUL1

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Alternative Name: MUL1

Background:

Synonyms: Mitochondrial ubiquitin ligase activator of NFKB 1|E3 SUMO-protein ligase MUL1|E3 ubiquitin-protein ligase MUL1|Growth inhibition and death E3 ligase|Mitochondrial-anchored protein ligase|Protein Hades|Putative NF-kappa-B-activating protein 266|RING finger protein 218|RING-type E3 ubiquitin transferase NFKB 1|MUL1|C1orf166|GIDE|MAPL|MULAN|RNF218

Background: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Molecular Weight: 35 kDa

Gene ID: 79594

UniProt: Q969V5

Pathways: Positive Regulation of Endopeptidase Activity