C20orf72 antibody

Catalog No. ABIN7116334

This Rabbit Polyclonal antibody specifically detects C20orf72 in ELISA, WB and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for C20orf72 antibody (ABIN7116334)

Target: C20orf72 (MGME1) (Mitochondrial Genome Maintenance Exonuclease 1 (MGME1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C20orf72 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-C20orf72 Antibody

Purpose: MGME1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: chromosome 20 open reading frame 72

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for C20orf72

Target: C20orf72 (MGME1) (Mitochondrial Genome Maintenance Exonuclease 1 (MGME1))

Alternative Name: MGME1

Background:

Synonyms: Mitochondrial genome maintenance exonuclease 1|MGME1|C20orf72|DDK1

Background: Metal-dependent single-stranded DNA(ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA(mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine(5hmC)-containing DNA in stem cells.

Molecular Weight: 36-39 kDa

Gene ID: 92667

UniProt: Q9BQP7